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google scholar profile of A. Mokhir


  1. Chercheja, S.; Daum, S.; Xu, H.; Beierlein, F.; Mokhir, A.* Hybrids of a 9-Anthracenyl Moiety and Fluorescein as Chemodosimeters for Detection of Singlet Oxygen in Live Cells. Org. Biomol. Chem., 2019, accepted.
  2. Zozulia, O.; Bachmann, T.; Deussner-Helfmann, N.; Beierlein, F.; Heilemann, M.; Mokhir, A.* Red Light-Triggered Nucleic Acid-Templated Reaction Based on Cyclic Oligonucleotide Substrates. Chemical Communications, 2019, 55(72), 10713-10716.
  3. Daum, S.; Toms, J.; Reshetnikov, V.; Özkan, H. G.; Hampel, F.; Maschauer, S.;  Hakimioun, A.; Beierlein, F; Sellner, L.; Schmitt, M.; Prante, O.;* Mokhir, A.* Active Form of N-Alkylaminoferrocene-Based Anticancer Prodrugs and Their Radiolabeling with 18F. Bioconjugate Chem., 2019, 30(4), 1077-1086.
  4. Zozulia, O.; Bachmann, T.; Mokhir, A.* Red Light Triggered Fluorogenic Reaction with Picomolar Sensitivity Towards Nucleic Acids. Bioconjugate Chem., 2019, 30(7), 2023-2031.
  5. Hahn, J.; Euler, M.; Kilgus, E.; Kienhöfer, D.; Stoof, J.; Knopf, J.; Hahn, M.; Harrer, T.; Hultqvist, M.; Olofsson, P.; Mokhir, A.; Holmdahl, R.; Herrmann, M.; Schett, G.; Muñoz, L. E.; Hoffmann, M. H.* NOX2 Mediates Qiuescent Handling of Dead Cell Remnants in Phagocytes. Redox Biol., 2019, 26, 101279.
  6. Kovalska, V.;* Vakarov, S.; Losytskyy, M.; Kuperman, M.; Chornenka, N.; Toporivska, Y.; Gumienna-Kontecka, E.; Voloshin, Y.; Varzatskii, O.; Mokhir, A. Dicarboxyl-Terminated Iron(II) Clathrochelates as ICD-Reporters for Globular Proteins. ACS Advances, 2019, 9(42), 24218-24230.
  7. Selin, R. A.; Chornenka, N. V.; Chernii, V. Ya.; Mokhir, A.; Vologzhanina, A. V.; Belov, A. S.; Pomadchik, A. L.; Voloshin, Y. Z.* Chemical Design of Heterodifunctionalized Iron(II) Clathrochelates with Terminal Biorelevant Carboxyl Group and Reactive Tripple C=C bond: Synthesis, Structure, Redox Properties and Their Stability in Various Media. Inorg. Chim. Acta, 2019, 496, 119047.
  8. Yoo, H. Y; Liu, Y.; Wang, L.; Schubert, M.-L.; Hoffmann, J.-M.; Wang, S.; Neuber, B.; Hückelhoven-Krauss, A.; Gern, U.; Schmitt, A.; Müller-Tidow, C.; Dreger, P.; Mokhir, A.; Schmitt, M.; Sellner, L.* Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies. Int. J. Mol. Sci., 2019, 20(10), 10.3390/ijms20102469.
  9. Karawacka, W.; Janko, C.; Unterweger, H.; Mühlberger, M.; Taccardi, N.; Mokhir, A.; Jira, W.; Peukert, W.; Boccaccini, A.; Kolot, M.; Alexiou, C.; Tietze, R.* SPIONs functionalized with small peptides for binding of lipopolysaccharide, a pathophysiologically relevant microbial product. Colloids & Surfaces B: Biointerfaces, 2019, 174 (Feb. 1), 95-102.


  1. Reshetnikov, V.; Daum, S.; Janko, C.; Karawacka, W.; Tietze, R.; Alexiou, C.; Paryzhak, S.; Dumych, T.; Bilyy, R.; Tripal, P.; Schmid, B.; Palmisano, R.; Mokhir, A.* ROS-responsive N-alkylaminoferrocenes for cancer cell specific targeting of mitochondriaAngew. Chem. Int. Ed., 2018, 57, 11943-11946.
  2. Reshetnikov, V.; Hahn, J.; Maueröder, C.; Czegley, C.; Munoz, L. E.; Herrmann, M.; Hoffmann, M. H.;* Mokhir, A.* Chemical tools for targeted amplification of reactive oxygen species in neutrophils. Frontiers in Immunology, 2018, Aug. 13: 9, 1827; doi: 10.3389/fimmu.2018.01827.
  3. Reshetnikov, V.; Arkhypov, A.; Julakanti, P. R., Mokhir, A.* A cancer specific oxaliplatin-releasing Pt(IV)-prodrugDalton Trans., 2018, 47, 6679-6682.
  4. Daum, S.; Babiy, S.; Konovalova, H.; Hofer, W.; Shtemenko, A.; Shtemenko, N.; Janko, C.; Alexiou, C.; Mokhir, A.* Tuning the structure of aminoferrocene-based anticancer prodrugs to prevent their aggregation in aqueous solution. J. Inorg. Biochem.2018, 178, 9-17.
  5. Dietrich, S;* Oleś, M;* Lu, J.; Sellner, L.; Anders, S.; Velten, B.; Wu, B.; Hüllein, J.; da Silva Liberio, M.; Walther, T.; Wagner, L.; Rabe, S.; Ghidelli-Disse, S.; Bantscheff, M.; Oleś, A. K.; Slabicki, M.; Mock, A.; Oakes, C.; Wang, S.; Oppermann, S.; Lukas, M.; Kim, V.; Sill, M.; Benner, A.; Jauch, A.; Sutton, L. A.; Young, E.; Rosenquist, R.; Liu, X.; Jethwa, A.; Lee, K. S.; Lewis, J.; Putzker, K.; Lutz, C.; Rossi, D.; Mokhir, A.; Oellerich, T.; Zirlik, K.; Herling, M.; Nguyen-Khac, F.; Plass, C.; Andersson, E.; Mustjoki, S.; von Kalle, C.; Ho, A. D.; Hensel, M.; Dürig, J.; Ringshausen, I.; Zapatka, M.; Huber, W.;* Zenz, T.* Drug perturbation based stratification of blood cancerJ. Clinical Investigation, 2018, 128(1), 427–445.
  6. Yan. Z. Voloshin,* Valentin V. Novikov, Yulia V. Nelyubina, Alexander S. Belov, Dmitrii M. Roitershtein, Anton Savitsky, Andriy Mokhir, Jörg Sutter, Matthias Miehlich, Karsten Meyer,* Synthesis and characterization of an Fe(I) cage complex with high stability towards strong H-acidsChem. Comm.2018, 54, 3436-3439.
  7. Toms, J.; Reshetnikov, V.; Maschauer, S.; Mokhir, A.; Prante, O.* Radiosynthesis of an 18F-fluoroglycosylated aminoferrocene for in-vivo imaging of reactive oxygen species activity by PETJ. Labelled Compounds & Radiopharmaceuticals2018, 61(14), 1081-1088.


  1. Daum, S.; Reshetnikov, V.; Sisa, M.; Dumych, T.; Lootsik, M. D.; Bilyy, R.; Bila, E.; Janko, C.; Alexiou, C.; Herrmann, M.; Sellner, L.; Mokhir, A.* Lysosome-targeting amplifiers of reactive oxygen species as anticancer prodrugs. Angew. Chem., 2017, 56(49), 15545-15549.
  2. Reshetnikov, V.; Daum, S.; Mokhir, A.* Cancer specific, intracellular, reductive activation of anticancer Pt(IV)-prodrugs. Chem. Eur. J., 2017, 23(24), 5678-5681.
  3. Kovalska, V.*; Kuperman, M.; Kryvorotenko, D.; Kinski, E.; Schikora, M.; Varzatskii, O.; Janko, C.; Alexiou, C.; Yarmoluk, S.; Mokhir, A.* [1,10]Phenanthroline based cyanine dyes as fluorescent probes for ribonucleic acids in live cells. Methods and Applications in Fluorescence, 2017, 5(4), 045002, DOI: 10.1088/2050-6120/aa8510.
  4. Chekhun, V. F.;* Lukianova, N. Y.; Borikun, T. V.; Zadvornyi, T. V.; Mokhir, A. Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics., Exp. Oncology, 2017, 39, 1, 25-29.
  5. Kovbasyuk, L.; Mokhir, A.* Toxicity studies and biomedical applications of graphene oxide. Book chapter (Graphene Oxide: Fundamentals and Applications, John Wiley  Sons Ltd, A. Dimiev, S. Eigler, Eds.), 2017.


  1. Pieper, H.; Chercheja, S.; Eigler, S.; Halbig, C.; Filipovic, M. R.; Mokhir, A.* Endoperoxides revealed as origin of toxicity of graphene oxide. Angew. Chem. Int. Ed 2016, 55(1), 405-407.
  2. Pieper, H.; Halbig, C. E.; Kovbasyuk, L.; M. R. Filipovic, Eigler, S.;* Mokhir, A.* Oxo-functionalized graphene as cell membrane carrier of nucleic acids probes controlled by aging. Chem. Eur. J., 2016, 22(43), 15389-15395.
  3. Meyer, A.; Schikora, M.; Starkuvienne, V.; Mokhir, A.* Red light activated „caged“ reagents for micro RNA research. Photochem. Photobiol. Sci., 2016, 15(9), 1120-1123.
  4. Schikora, M.; Mokhir, A.* Cu(II)-complexes as quenchers of photocatalytic activity of visible light-absorbing photosensitizers: an application in detection of nucleic acids. Inorg. Chim. Acta, 2016, (special issue on „Metal-nucleic acid interactions – state of the art“). 452, 118-124.
  5. Kinski, E.; Marzenell, P.; Hofer, W.; Hagen, H.; Raskatov J. A.; Knaup, K. X.; Zolnhofer, E. M.; Meyer, K.; Mokhir, A.* 4-Azidobenzyl ferrocenylcarbamate as an anticancer prodrug activated at reductive conditions. J. Inorg. Biochem. 2016, 160, 218-224 (special issue: Metallodrugs/COST action).
  6. Blechinger, J.; Varzackii, O.; Kovalska, V.; Zelinskii, G. E.; Voloshin, Y. Z.; Mokhir, A.* Cytotoxicity of electrophilic iron(II)-clathrochelates in human promyelocytic leukemia cell line. Bioorg. Med. Chem. Lett. 2016, 26(2), 626-629.
  7. Beierlein, F. R.;* Palomo, M. P.; Sharapa, D. I.; Zozulia, O.; Mokhir, A.; Clark, T. DNA-dye-conjugates: conformation and spectra of fluorescence probes. PLOS ONE, 2016, 11(7), e0160229.


  1. Meyer, A.; Schikora, M.; Mokhir, A.* Red light controlled polymerase chain reaction. Chem. Comm. (2015), 51, 13324-13326.
  2. Daum, S.; Chekhun, V.; Todor, I.; Lukianova, N.; Shvets, Y.; Sellner, L.; Putzker, K.; Lewis, J.; Zenz, T.; Graaf, I.; Groothuis, G.; Casini, A.; Zozulia, O.; Hampel, F.; Mokhir, A.* Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity. J. Med. Chem. (2015), 58(4), 2015-2024.
  3. Schikora, M.; Reznikov, A.; Chaykovskaya, L.; Sachinska, O.; Polyakova, L.; Mokhir, A.* Activity of aminoferrocene-based prodrugs against prostate cancerBioorg. Med. Chem. Lett. (2015), 25(17), 3447-3450.
  4. Mokhir, A.* Chemical reactions controlled by nucleic acids. Book chapter (DNA in Supramolecular Chemistry and Nanotechnology, John Wiley & Sons, Ltd, Eds. E. Stulz and G. H. Clever). 2015. ISBN: 978-1-118-69686-6.
  5. Chekhun, V.F.; Mokhir, A.; Daum, S.; Todor, I.N.*; Lukianova, N.Yu.; Shvets, Yu.V.; Burlaka, A.P. Pharmacological effect of aminoferrocene in mice with L1210 leukemia. Exp. Oncology. (2015), 37(2), 120-125.


  1. Meyer, A.; Mokhir, A.* RNA interference controlled by light of variable wavelength. Angew. Chem. Int. Ed., (2014), 53(47), 12840-12843.
  2. Marzenell, P.; Hagen, H.; Blechinger, J.; Erfle, H.; Mokhir, A.* Terminally modified, short phosphorothioate oligonucleotides as inhibitors of gene expression in cells. Bioorg. Med. Chem. Lett., (2014), 24(19), 4694-4698.
  3. Kovalska, V. B.;* Losytskyy, M. Yu.; Varzatskii, O. A.; Cherepanov, V. V.; Voloshin, Y. Z.; Mokhir, A.; Yarmoluk, S. M.; Volkov, S. V. Study of anti-fibrinogenic activity of iron(II) clathrochelates, Bioorg. Med. Chem., (2014), 22(6), 1883-1888.
  4. Schikora, M., Dutta, S.; Mokhir, A.* Nucleic acid – specific photoactivation of oligodeoxyribonucleotides labeled with deuterated dihydro-N,N,N‘,N‘-tetramethylrhodamine using green light, Histochem. Cell Biol., (2014), 142(1), 103-111.


  1. König, S.; Mokhir, A.* „Caged“ peptide nucleic acids activated by red light in a singlet oxygen-mediated process, Bioorg. Med. Chem. Lett., (2013), 23(24), 6544-6548.
  2. Marzenell, P.; Hagen, H.; Sellner, L.; Zenz, T.; Grinyte, R.; Pavlov, V.; Daum, S.; Mokhir, A.* Aminoferrocene-based prodrugs and their effects on human normal and cancer as well as bacterial cells, J. Med. Chem., (2013), 56(17), 6935-6944.
  3. Dutta, S.; Fülöp, A.; Mokhir, A.* A fluorogenic, catalytic, photochemical reaction for amplified detection of nucleic acidsBioconjugate Chemistry, (2013), 24(9), 1533-1542.
  4. Degtyarenko, A. S.; Rusanov, E. B.; Bauza, A.; Frontera, A.; Krautscheid, H.; Chernega, A. N.; Mokhir, A.; Domasevitch, K. V.*, Self-assembly cavitand precisely recognizing hexafluorosilicate: a concerted action of two coordination and twelve CH…F bonds, Chem. Comm., (2013), 49(79), 9018-9020.
  5. Dolganov, A. V.; Belov, A. S.; Novikov, V. V.; Vologzhanina, A. V.; Mokhir, A.; Bubnov, Y. N.; Voloshin, Y. Z.* Iron vs. cobalt clathrochelate electrocatalysis of HER: the first example on a cage iron complex, Dalton Trans, (2013), 42, 4373-4376.
  6. Blechinger, J.; Pieper, H.; Marzenell, P.; Kovbasyuk, L.; Serva, A.; Starkuviene, V.; Erfle, H.; Mokhir, A. * Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA, Chem. Comm., (2013), 49, 7397-7399.


  1. Dutta, S.; Flottmann, B.; Heilemann, M.; Mokhir, A.* Hybridization and reaction-based, fluorogenic nucleic acid probes, Chem. Comm. (2012), 47, 9664-9666.
  2. Hagen, H.; Marzenell, P.; Jentzsch, E.; Wenz, F.; Veldwijk, M. R.; Mokhir, A.* Aminoferrocene-Based Prodrugs Activated by Reactive Oxygen SpeciesJ. Med. Chem., (2012), 55(2), 924-934.
  3. Krämer, R.* und Mokhir, A. Metal Complex Derivatives of Peptide Nucleic Acids in „Interplay between Metal Ions and Nucleic Acids“, Vol. 10 of ‚Metal Ions in Life Sciences‘, A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; Springer Science + Business Media B.V., Dordrecht, 2012, chapter 12, pp. 319-340.


  1. Arian, D.; Kovbasyuk, L.; Mokhir, A.* Control of the Photocatalytic Activity of Bimetallic Complexes of Pyropheophorbide-a by Nucleic Acids, Inorg. Chem., (2011), 50(23), 12010-12017.
  2. Arian, D.; Kovbasyuk, L.; Mokhir, A.* 1,9-Di(alkoxy)anthracene as a Singlet Oxygen-Sensitive Linker, J. Am. Chem. Soc. (2011), 133(11), 3972-3980.
  3. Dutta, S.; Mokhir, A.* An autocatalytic chromogenic and fluorogenic photochemical reaction controlled by nucleic acids, Chem. Comm. (2011), 47(4), 1243-1245.


  1. Helmig, S.; Rotaru, A.; Arian, D.; Kovbasyuk, L.; Arnbjerg, J.; Ogilby, P.R.; Kjems, J.; Mokhir, A., Besenbacher, F.; Gothelf, K.V.* Single Molecule AFM Studies of Photosensitized Singlet Oxygen Behavior on a DNA Origami Template, ACS Nano. (2010), 4(12), 7475-7480.
  2. Rotaru, A.; Dutta, S. Jentzsch, E.; Gothelf, K. V.; Mokhir, A.* Selective dsDNA-templated formation of copper nanoparticles in solution. Angew. Chem. (2010), 122(33), 5799-5802.
  3. Fülöp, A.; Peng, X.; Greenberg, M.M.; Mokhir, A.* A nucleic acid directed, red light- induced chemical reaction. Chem. Comm. (2010), 46, 5659-5661.
  4. Voigt, N.V.; Tørring, T.; Rotaru, A.; Jacobsen, M.F.; Ravnsbæk, J.B.; Subramani, R.; Mamdouh, W.; Kjems, J.; Mokhir, A.; Besenbacher, F.; Gothelf, K.V.* Single Molecule Chemical Reactions on DNA Origami. Nature Nanotech. (2010), 5, 200-203.
  5. Arian, D.; Cló, E.; Gothelf, K.V.; Mokhir, A.* A nucleic acid dependent chemical photocatalysis in live cells. Chem., Eur. J. (2010), 16(1), 288-295.